Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit
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Characteristics of phosphorylated and non-phosphorylated dentine phosphoprotein.
Heterogeneity among the odontoblast-specific, highly phosphorylated acidic protein dentine phosphoprotein (DPP) obtained from different species has been reported by several investigators. In the present study, the apparent molecular-mass variations in rabbit and mouse DPP were investigated. Extracellular matrix (ECM) DPPs were isolated and characterized. Primary gene products, before post-trans...
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In 1928 Miiller (1) reported the presence of a new enzyme, a glucose oxidase, in press-juice of Aspergillus niger. He subsequently suggested that it might be a dehydrogenase (2) ; he later showed that it catalyzed the oxidation of glucose to gluconic acid (3). Harrison in 1931 obtained glucose dehydrogenase from acetone-dried mammalian liver by saturating a water extract with ammonium sulfate (...
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XRCC1 plays a central role in mammalian single-strand break repair. Although it has no enzymatic activity of its own, it stimulates the activities of polynucleotide kinase/phosphatase (PNKP), and this function is enhanced by protein kinase CK2 mediated phosphorylation of XRCC1. We have previously shown that non-phosphorylated XRCC1 stimulates the kinase activity of PNKP by increasing the turnov...
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PINK1 selectively recruits Parkin to depolarized mitochondria for quarantine and removal of damaged mitochondria via ubiquitylation. Dysfunction of this process predisposes development of familial recessive Parkinson's disease. Although various models for the recruitment process have been proposed, none of them adequately explain the accumulated data, and thus the molecular basis for PINK1 recr...
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10 H. Beinert and P. G. Stansly, J. Biol. Chem., 204, 67, 1953. 1 D. E. Green, D. S. Goldman, S. Mii, and H. Beinert, J. Biol. Chem., 202, 137, 1953. 12 E. R. Stadtman and H. A. Barker, J. Biol. Chem., 184, 769, 1950. '3 E. R. Stadtman, J. Biol. Chem., 196, 535, 1952. 14 A. A. Benson, J. A. Bassham, M. Calvin, T. C. Goodale, V. A. Haas, and W. Stepka, J. Am. Chem. Soc., 72, 1710, 1950. 15 F. Ly...
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ژورنال
عنوان ژورنال: CCS Chemistry
سال: 2019
ISSN: 2096-5745
DOI: 10.31635/ccschem.019.20190001